VIP

Across TCGA cell cohorts, VIP RNA expression is significantly associated with the go_rna of many other GO terms, with 660 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible VIP-associated GO terms across cancer lineages are Regulation of protein exit from endoplasmic reticulum, Nucleotide-sugar biosynthetic process, and Cellular response to unfolded protein. Each is linked with VIP in more than 4 cancer types. Because this analysis shows association rather than direction, both VIP-to-partner and partner-to-VIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein exit from endoplasmic reticulum grouped by VIP-low versus VIP-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VIP→partner) and Y-score (partner→VIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of protein exit from endoplasmic reticulum →	+0.077	+0.072	<.001	.001	3	5
CNS	Nucleotide-sugar biosynthetic process →	+0.062	+0.077	<.001	.001	2	5
LUNG_NSCLC_LUAD	Cellular response to unfolded protein →	+0.073	+0.155	<.001	.001	3	4
SOFT_TISSUE	Positive regulation of protein exit from endoplasmic reticulum →	+0.101	+0.249	<.001	.002	2	4
SOFT_TISSUE	Amyloid-beta clearance →	+0.080	+0.649	.004	.004	3	3
SKIN	Positive regulation of DNA-directed DNA polymerase activity →	-0.106	-0.136	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 660 associations by consensus.

Regulation of protein exit from endoplasmic reticulum by VIP expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →