VIM

Across TCGA patient cohorts, VIM protein abundance is significantly associated with the RNA expression of many other genes, with 18,442 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible VIM-associated genes across cancer lineages are SRPX, OLFML3, and AOC3. Each is linked with VIM in more than 8 cancer types. Because this analysis shows association rather than direction, both VIM-to-partner and partner-to-VIM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, VIM versus SRPX in BRCA, with a Pearson correlation of 0.70.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VIM→partner) and Y-score (partner→VIM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SRPX →	+1.527	+0.601	<.001	<.001	3	9
BRCA	OLFML3 →	+1.181	+0.519	<.001	<.001	3	9
BRCA	AOC3 →	+1.368	+0.477	<.001	<.001	3	9
LSCC	COLEC12 →	+0.990	+0.467	<.001	<.001	3	9
GBM	IGFBP7 →	+0.941	+0.400	<.001	<.001	3	9
BRCA	LRRN4CL →	+1.140	+0.499	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,442 associations by consensus.

VIM vs SRPX — BRCA

Explore this scatter interactively →