VIM

Across TCGA pan-cancer cohorts, VIM RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated VIM data layer compared with 6 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher VIM RNA is associated with better overall survival. In most high-consensus cancer types, elevated VIM expression acts as an unfavorable survival marker, although some lineages such as UVM and UCEC show a favorable association.

UVM, MESO, and UCEC are the cancer types where VIM RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	II,III,IV	0.795	0.355	<.001	128	view →
MESO	OS	Median	All	0.415	0.663	<.001	105	view →
UCEC	DFS	Median	All	0.809	0.556	<.001	100	view →
ACC	DFS	Tertile	All	0.396	0.836	<.001	98	view →
LGG	DFS	Median	All	0.632	0.849	<.001	53	view →
STAD	OS	Tertile	All	0.522	0.701	.001	51	view →
BLCA	OS	Tertile	All	0.538	0.678	.007	35	view →
KIRP	DFS	Quartile	III,IV	0.459	0.902	.001	29	view →
SARC	DFS	Median	All	0.404	0.623	<.001	25	view →
HNSC	DFS	Quartile	III,IV	0.612	0.421	.020	13	view →
UCS	DFS	Tertile	IV	0.996	0.394	.024	12	view →
COAD	DFS	Median	All	0.401	0.571	.019	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

VIM–UVM (OS)

Open the UVM breakdown →