VIM

Across TCGA patient cohorts, VIM mutation is significantly associated with the RNA expression of many other genes, with 2,084 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VIM-associated genes across cancer lineages are SELENOWP1, CMC1, and RNU6-1068P. Each is linked with VIM in more than 2 cancer types. Because this analysis shows association rather than direction, both VIM-to-partner and partner-to-VIM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SELENOWP1 grouped by VIM-low versus VIM-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VIM→partner) and Y-score (partner→VIM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	SELENOWP1 →	+0.374	+2.536	<.001	.007	3	3
UCEC	CMC1 →	+0.331	+2.823	.005	.001	3	3
COAD	RNU6-1068P →	+0.493	+5.602	<.001	.004	3	2
LUAD	OR7E96P →	+0.090	+4.444	<.001	.006	3	2
LUSC	PARD6A →	+0.740	+3.459	.006	.005	3	2
LUSC	ANKRD49 →	+0.485	+3.205	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,084 associations by consensus.

SELENOWP1 by VIM expression — LUSC

Explore this box plot interactively →