VIM

Across TCGA patient cohorts, VIM mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VIM-associated genes across cancer lineages are Notch1, p62 Lck ligand, and FOXO3a_pS318_S321. Each is linked with VIM in more than 1 cancer types. Because this analysis shows association rather than direction, both VIM-to-partner and partner-to-VIM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by VIM-low versus VIM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VIM→partner) and Y-score (partner→VIM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.158	+2.335	.006	.018	3	2
UCEC	p62 Lck ligand →	+0.546	+3.710	<.001	<.001	3	2
UCEC	FOXO3a_pS318_S321 →	-0.113	-1.990	.027	.030	3	1
UCEC	INPP4B →	-0.275	-3.169	.039	.018	3	1
UCEC	MAPK_pT202_Y204 →	-0.478	-1.807	.013	.027	3	1
UCEC	NF-kB-p65_pS536 →	-0.416	-2.312	.026	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Notch1 by VIM expression — UCEC

Explore this box plot interactively →