VIM

Across TCGA cell cohorts, VIM RNA expression is significantly associated with the go_rna of many other GO terms, with 6,436 significant associations in total. BONE shows the largest number of these associations.

The most reproducible VIM-associated GO terms across cancer lineages are Regulation of collagen metabolic process, Peptidyl-lysine oxidation, and Establishment of epithelial cell apical/basal polarity. Each is linked with VIM in more than 15 cancer types. Because this analysis shows association rather than direction, both VIM-to-partner and partner-to-VIM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of collagen metabolic process grouped by VIM-low versus VIM-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VIM→partner) and Y-score (partner→VIM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of collagen metabolic process →	+0.185	+5.786	.002	.001	3	16
LUNG_NSCLC_LUSC	Peptidyl-lysine oxidation →	+1.683	+6.111	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Establishment of epithelial cell apical/basal polarity →	+0.248	+5.957	<.001	<.001	3	15
KIDNEY	Regulation of collagen biosynthetic process →	+0.161	+1.432	<.001	.001	3	15
LIVER	Positive regulation of collagen biosynthetic process →	+0.226	+6.456	.001	.001	3	15
LUNG_NSCLC_LUSC	Cellular response to muramyl dipeptide →	+0.216	+6.298	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,436 associations by consensus.

Regulation of collagen metabolic process by VIM expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →