VIM-AS1

Across TCGA pan-cancer cohorts, VIM-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of VIM-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where VIM-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types VIM-AS1 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KIRC, and KICH are the cancer types where VIM-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VIM-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−0.578	<.001	11	view →
KIRC	Male	All	+0.621	<.001	9	view →
KICH	Female	II,III,IV	−1.900	<.001	8	view →
LUSC	Male	II,III,IV	−1.455	<.001	8	view →
LUAD	Male	II,III,IV	−1.229	<.001	8	view →
BRCA	All	III,IV	−1.180	<.001	6	view →
BLCA	Female	All	−0.747	.019	6	view →
CHOL	Male	All	+2.700	<.001	3	view →
PRAD	All	All	−0.461	<.001	2	view →
HNSC	All	III,IV	+0.425	.019	2	view →
THCA	All	II,III,IV	+0.227	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

VIM-AS1–COAD

Open the COAD breakdown →