VILL

Across TCGA cell cohorts, VILL mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VILL-associated genes across cancer lineages are H4C6, TBX18, and CCDC54. Each is linked with VILL in more than 1 cancer types. Because this analysis shows association rather than direction, both VILL-to-partner and partner-to-VILL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H4C6 grouped by VILL-low versus VILL-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VILL→partner) and Y-score (partner→VILL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	H4C6 →	+0.270	+4.212	<.001	.007	3	1
LARGE_INTESTINE	TBX18 →	+1.413	+3.215	<.001	.009	3	1
LARGE_INTESTINE	CCDC54 →	+0.090	+2.669	.006	.007	3	1
LARGE_INTESTINE	PGGT1B →	+0.768	+3.169	.008	.005	3	1
LARGE_INTESTINE	MINAR1 →	+0.551	+3.082	.002	.007	3	1
LARGE_INTESTINE	OR10W1 →	+0.008	+2.977	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

H4C6 by VILL expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →