VIL1

Across TCGA patient cohorts, VIL1 mutation is significantly associated with the RNA expression of many other genes, with 2,756 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VIL1-associated genes across cancer lineages are RNU6-340P, HMGA1P6, and MIR378E. Each is linked with VIL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both VIL1-to-partner and partner-to-VIL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-340P grouped by VIL1-low versus VIL1-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VIL1→partner) and Y-score (partner→VIL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	RNU6-340P →	+0.409	+4.620	<.001	.004	3	3
BLCA	HMGA1P6 →	+0.136	+4.463	.001	.005	3	3
COAD	MIR378E →	+0.409	+5.136	<.001	.002	3	3
LGG	RPS20P25 →	+0.098	+5.032	<.001	.004	3	2
UCEC	SKA1 →	+0.589	+2.161	<.001	<.001	3	2
UCEC	CHAF1B →	+0.489	+2.338	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,756 associations by consensus.

RNU6-340P by VIL1 expression — LGG

Explore this box plot interactively →