VIL1

Across TCGA pan-cancer cohorts, VIL1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of VIL1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where VIL1 RNA is repressed in tumor relative to normal tissue. In most cancer types VIL1 is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRP, KICH, and LUAD are the cancer types where VIL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VIL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Female	II,III,IV	−3.774	<.001	11	view →
KICH	Male	II,III,IV	−3.085	<.001	10	view →
LUAD	Male	II,III,IV	+1.729	<.001	7	view →
STAD	All	All	+2.571	<.001	6	view →
HNSC	All	All	+0.135	.025	5	view →
CHOL	Male	All	+3.443	.001	4	view →
BRCA	Female	All	+0.165	<.001	4	view →
LIHC	All	All	+0.847	.016	2	view →
LUSC	All	All	+0.602	<.001	2	view →
UCEC	All	All	+0.454	.035	2	view →
ESCA	All	All	+2.845	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

VIL1–KIRP

Open the KIRP breakdown →