VIL1

Across TCGA patient cohorts, VIL1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VIL1-associated genes across cancer lineages are Myosin-IIa, Smac, and STAT3_pY705. Each is linked with VIL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VIL1-to-partner and partner-to-VIL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Myosin-IIa grouped by VIL1-low versus VIL1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VIL1→partner) and Y-score (partner→VIL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Myosin-IIa →	+0.189	+2.836	.045	.030	3	2
SKCM	Smac →	+0.214	+1.498	.022	.032	3	2
SKCM	STAT3_pY705 →	-0.231	-1.840	.013	.047	3	2
UCEC	MEK1 →	+0.396	+2.087	<.001	.005	3	2
UCEC	TIGAR →	+0.136	+1.965	.006	<.001	3	2
UCEC	4E-BP1 →	+0.238	+3.459	.007	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Myosin-IIa by VIL1 expression — SKCM

Explore this box plot interactively →