Across TCGA patient cohorts, VHLL mutation is significantly associated with the RNA expression of many other genes, with 113 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VHLL-associated genes across cancer lineages are TRAJ25, TSEN2P1, and USP9YP10. Each is linked with VHLL in more than 1 cancer types. Because this analysis shows association rather than direction, both VHLL-to-partner and partner-to-VHLL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VHLL→partner) and Y-score (partner→VHLL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TRAJ25 →	+0.666	+4.074	.001	.001	3	2
COAD	TSEN2P1 →	+0.228	+5.017	<.001	.009	3	1
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	1
LGG	MCUR1P2 →	+0.074	+7.977	<.001	.007	3	1
UCEC	CTHRC1P1 →	+0.111	+3.472	.005	.004	3	1
UCEC	MIR8071-1 →	+1.462	+3.214	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 113 associations by consensus.

Exploration

VHLL survival (RNA) · tumor vs normal (RNA) · all VHLL data types