VHL

Across TCGA patient cohorts, VHL protein abundance is significantly associated with the RNA expression of many other genes, with 8,097 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible VHL-associated genes across cancer lineages are FEZ1, TRAF6, and RNF24. Each is linked with VHL in more than 1 cancer types. Because this analysis shows association rather than direction, both VHL-to-partner and partner-to-VHL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, VHL versus FEZ1 in HNSC, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VHL→partner) and Y-score (partner→VHL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FEZ1 →	+0.975	+0.494	.001	.004	3	2
GBM	TRAF6 →	-0.354	-0.269	<.001	.005	3	2
PDAC	RNF24 →	+1.049	+0.514	.005	.004	3	2
OV	PLA2R1 →	+0.769	+0.412	.001	<.001	3	2
BRCA	SLC18A2 →	+1.045	+0.405	.001	<.001	3	2
PDAC	TMEM43 →	+1.011	+0.540	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,097 associations by consensus.

VHL vs FEZ1 — HNSC

Explore this scatter interactively →