VHL

Across TCGA pan-cancer cohorts, VHL RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of VHL’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where VHL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types VHL is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

BLCA, COAD, and STAD are the cancer types where VHL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VHL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	+1.438	<.001	10	view →
COAD	Male	II,III,IV	+0.612	<.001	9	view →
STAD	Male	II,III,IV	+1.181	<.001	8	view →
LUAD	Male	All	+0.575	<.001	7	view →
THCA	All	All	−0.474	<.001	7	view →
KIRC	Male	II,III,IV	−0.557	<.001	6	view →
LIHC	All	All	+0.556	<.001	6	view →
KICH	Female	All	−0.977	<.001	5	view →
CHOL	All	All	+1.112	<.001	4	view →
READ	Female	All	+0.806	<.001	4	view →
LUSC	Male	All	+0.394	<.001	4	view →
BRCA	All	II,III,IV	+0.344	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

VHL–BLCA

Open the BLCA breakdown →