VHL

Across TCGA patient cohorts, VHL mutation is significantly associated with the RNA expression of many other genes, with 468 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible VHL-associated genes across cancer lineages are RNU6-746P, MTCO3P41, and C11orf40. Each is linked with VHL in more than 1 cancer types. Because this analysis shows association rather than direction, both VHL-to-partner and partner-to-VHL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-746P grouped by VHL-low versus VHL-high in KIRC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VHL→partner) and Y-score (partner→VHL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	RNU6-746P →	+0.033	+2.659	<.001	<.001	3	2
UCEC	MTCO3P41 →	+0.419	+5.073	<.001	.001	3	2
PCPG	C11orf40 →	+0.135	+5.230	<.001	.006	3	1
PCPG	POM121L1P →	+0.038	+5.230	<.001	.006	3	1
PCPG	SERPINA13P →	+0.035	+6.112	<.001	.001	3	1
PCPG	RNU6-694P →	+0.427	+5.230	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 468 associations by consensus.

RNU6-746P by VHL expression — KIRC

Explore this box plot interactively →