VHL

Across TCGA cell cohorts, VHL RNA expression is significantly associated with the RNA expression of many other genes, with 11,484 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible VHL-associated genes across cancer lineages are RAF1, SETD5, and RBSN. Each is linked with VHL in more than 18 cancer types. Because this analysis shows association rather than direction, both VHL-to-partner and partner-to-VHL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, VHL versus RAF1 in URINARY_TRACT, with a Pearson correlation of 0.65.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VHL→partner) and Y-score (partner→VHL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RAF1 →	+1.427	+1.232	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	SETD5 →	+1.702	+1.617	<.001	<.001	3	19
OESOPHAGUS	RBSN →	+1.232	+1.231	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	EAF1 →	+1.359	+2.038	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	TATDN2 →	+1.214	+1.514	<.001	<.001	3	18
STOMACH	NR2C2 →	+1.318	+1.164	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,484 associations by consensus.

VHL vs RAF1 — URINARY_TRACT

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