VHL

Across TCGA cell cohorts, VHL RNA expression is significantly associated with the go_rna of many other GO terms, with 4,238 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VHL-associated GO terms across cancer lineages are Regulation of mRNA catabolic process, Heterochromatin formation, and P-body assembly. Each is linked with VHL in more than 15 cancer types. Because this analysis shows association rather than direction, both VHL-to-partner and partner-to-VHL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mRNA catabolic process grouped by VHL-low versus VHL-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VHL→partner) and Y-score (partner→VHL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of mRNA catabolic process →	+0.066	+2.017	<.001	.002	3	16
UPPER_AERODIGESTIVE_TRACT	Heterochromatin formation →	+0.080	+1.858	<.001	<.001	3	16
STOMACH	P-body assembly →	+0.128	+0.908	<.001	.002	3	16
BONE	Epigenetic regulation of gene expression →	+0.081	+0.849	<.001	<.001	3	16
OVARY	Transcription elongation by RNA polymerase II →	+0.094	+0.895	<.001	<.001	3	16
BLOOD_Lymphoma	Positive regulation of mRNA catabolic process →	+0.068	+1.307	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,238 associations by consensus.

Regulation of mRNA catabolic process by VHL expression — KIDNEY

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