VGLL4

Across TCGA patient cohorts, VGLL4 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VGLL4-associated genes across cancer lineages are MEK1, Rab25, and Shc_pY317. Each is linked with VGLL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both VGLL4-to-partner and partner-to-VGLL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by VGLL4-low versus VGLL4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VGLL4→partner) and Y-score (partner→VGLL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.528	+3.321	.004	.010	3	1
UCEC	Rab25 →	-0.401	-3.000	.016	.036	3	1
UCEC	Shc_pY317 →	-0.225	-2.321	.003	.035	3	1
UCEC	VHL →	-1.412	-3.459	<.001	.005	3	1
UCEC	Caspase-8 →	-0.347	-3.459	.005	.005	1	1
UCEC	C-Raf →	+0.225	+2.321	.001	.035	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MEK1 by VGLL4 expression — UCEC

Explore this box plot interactively →