VGLL4

Across TCGA pan-cancer cohorts, VGLL4 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of VGLL4’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where VGLL4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types VGLL4 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

BLCA, COAD, and THCA are the cancer types where VGLL4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VGLL4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	+0.705	.001	10	view →
COAD	Male	III,IV	+0.796	<.001	9	view →
THCA	Male	All	−0.851	<.001	8	view →
LIHC	Female	All	+0.931	<.001	6	view →
READ	Male	All	+0.510	.005	6	view →
HNSC	All	All	+0.445	.004	6	view →
KIRC	All	II,III,IV	−0.375	<.001	6	view →
CHOL	Male	All	+2.161	<.001	5	view →
STAD	Male	II,III,IV	+0.878	<.001	5	view →
KICH	All	All	−0.667	<.001	5	view →
LUSC	All	II,III,IV	+0.539	<.001	5	view →
UCEC	All	All	−0.905	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

VGLL4–BLCA

Open the BLCA breakdown →