VGLL4

Across TCGA cell cohorts, VGLL4 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VGLL4-associated genes across cancer lineages are APLNR and WDR87. Each is linked with VGLL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both VGLL4-to-partner and partner-to-VGLL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APLNR grouped by VGLL4-low versus VGLL4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VGLL4→partner) and Y-score (partner→VGLL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	APLNR →	+0.290	+3.799	<.001	.003	2	1
LARGE_INTESTINE	WDR87 →	+0.017	+3.453	.003	.009	2	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

APLNR by VGLL4 expression — LARGE_INTESTINE

Explore this box plot interactively →