Across TCGA patient cohorts, VGLL3 mutation is significantly associated with the RNA expression of many other genes, with 2,566 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VGLL3-associated genes across cancer lineages are ACTR5, PARP6, and LINC02758. Each is linked with VGLL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both VGLL3-to-partner and partner-to-VGLL3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VGLL3→partner) and Y-score (partner→VGLL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ACTR5 →	+0.381	+3.477	.004	.002	3	3
SKCM	PARP6 →	+0.679	+2.497	<.001	.009	3	3
SKCM	LINC02758 →	+0.120	+2.639	<.001	.006	3	3
READ	EEF1E1-BLOC1S5 →	+0.204	+5.219	<.001	.006	3	3
UCEC	GARS1 →	+0.471	+2.130	<.001	.002	3	3
LUAD	LAMB2P1 →	+0.525	+3.375	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,566 associations by consensus.

Exploration

VGLL3 survival (RNA) · tumor vs normal (RNA) · all VGLL3 data types