Across TCGA cell cohorts, VGLL3 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible VGLL3-associated genes across cancer lineages are OR1E2, OR4X2, and OR3A1. Each is linked with VGLL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both VGLL3-to-partner and partner-to-VGLL3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VGLL3→partner) and Y-score (partner→VGLL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR1E2 →	+0.016	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR4X2 →	+0.023	+4.947	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR3A1 →	+0.774	+4.544	<.001	.003	3	1
LUNG_NSCLC_LUAD	OC90 →	+0.019	+4.371	<.001	.005	3	1
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	KRTAP10-2 →	+0.061	+3.994	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

VGLL3 survival (RNA) · tumor vs normal (RNA) · all VGLL3 data types