VGF

Across TCGA cell cohorts, VGF mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VGF-associated genes across cancer lineages are ADRA1A, CHST8, and NAA11. Each is linked with VGF in more than 1 cancer types. Because this analysis shows association rather than direction, both VGF-to-partner and partner-to-VGF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADRA1A grouped by VGF-low versus VGF-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VGF→partner) and Y-score (partner→VGF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADRA1A →	+0.132	+3.103	.002	.004	3	1
LARGE_INTESTINE	CHST8 →	+0.181	+3.643	<.001	.005	3	1
LARGE_INTESTINE	NAA11 →	+0.315	+3.706	.007	.002	3	1
LARGE_INTESTINE	OR2C1 →	+0.090	+3.426	.004	.007	3	1
LARGE_INTESTINE	OR1L6 →	+0.015	+3.700	<.001	.009	3	1
LARGE_INTESTINE	NUPR2 →	+0.230	+3.103	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ADRA1A by VGF expression — LARGE_INTESTINE

Explore this box plot interactively →