VEZT

Across TCGA cell cohorts, VEZT mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible VEZT-associated genes across cancer lineages are CENPVL1, LINGO4, and C8orf74. Each is linked with VEZT in more than 1 cancer types. Because this analysis shows association rather than direction, both VEZT-to-partner and partner-to-VEZT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPVL1 grouped by VEZT-low versus VEZT-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VEZT→partner) and Y-score (partner→VEZT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CENPVL1 →	+0.289	+4.234	<.001	.003	3	2
LARGE_INTESTINE	LINGO4 →	+0.147	+3.807	<.001	.001	3	2
SOFT_TISSUE	C8orf74 →	+0.029	+5.369	<.001	.004	3	1
LARGE_INTESTINE	TFDP3 →	+0.024	+2.933	<.001	.003	3	1
LARGE_INTESTINE	PNMA3 →	+0.170	+2.781	<.001	.009	3	1
SKIN	KRT35 →	+0.036	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

CENPVL1 by VEZT expression — BLOOD_Leukemia

Explore this box plot interactively →