VENTX

Across TCGA patient cohorts, VENTX mutation is significantly associated with the RNA expression of many other genes, with 176 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible VENTX-associated genes across cancer lineages are RNA5SP407, MIR328, and RNU7-141P. Each is linked with VENTX in more than 1 cancer types. Because this analysis shows association rather than direction, both VENTX-to-partner and partner-to-VENTX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP407 grouped by VENTX-low versus VENTX-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VENTX→partner) and Y-score (partner→VENTX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNA5SP407 →	+0.238	+7.954	<.001	.008	3	2
LUAD	MIR328 →	+0.249	+3.458	.006	.003	3	2
LUAD	RNU7-141P →	+0.545	+3.202	.002	.006	3	2
LIHC	LINC00681 →	+0.093	+6.149	<.001	.002	3	2
LIHC	KRTAP21-1 →	+0.069	+5.758	<.001	.003	3	2
LIHC	RPL31P59 →	+0.135	+6.479	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 176 associations by consensus.

RNA5SP407 by VENTX expression — HNSC

Explore this box plot interactively →