VEGFA

Across TCGA patient cohorts, VEGFA mutation is significantly associated with the RNA expression of many other genes, with 3,867 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VEGFA-associated genes across cancer lineages are OR7E8P, HAUS1, and BUB3. Each is linked with VEGFA in more than 1 cancer types. Because this analysis shows association rather than direction, both VEGFA-to-partner and partner-to-VEGFA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR7E8P grouped by VEGFA-low versus VEGFA-high in GBM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VEGFA→partner) and Y-score (partner→VEGFA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	OR7E8P →	+0.066	+5.149	<.001	.007	3	2
UCEC	HAUS1 →	+0.562	+1.868	<.001	<.001	3	2
UCEC	BUB3 →	+0.508	+4.323	<.001	<.001	3	2
UCEC	ADK →	+0.506	+2.158	<.001	<.001	3	2
UCEC	HIPK4 →	-0.200	-2.665	.004	.003	3	2
UCEC	NDUFB6 →	+0.628	+2.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,867 associations by consensus.

OR7E8P by VEGFA expression — GBM

Explore this box plot interactively →