VEGFA

Across TCGA pan-cancer cohorts, VEGFA RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated VEGFA data layer compared with 7 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher VEGFA RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated VEGFA expression acts as an unfavorable survival marker, although some lineages such as BLCA and SKCM show a favorable association.

KIRP, UVM, and CESC are the cancer types where VEGFA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.775	0.929	<.001	164	view →
UVM	DFS	Median	All	0.422	0.767	<.001	82	view →
CESC	OS	Median	All	0.728	0.864	.002	68	view →
BRCA	OS	Tertile	II,III,IV	0.882	0.952	.001	55	view →
LGG	OS	Median	All	0.356	0.517	<.001	47	view →
LIHC	DFS	Median	All	0.439	0.643	<.001	43	view →
ACC	DFS	Median	All	0.439	0.727	.001	41	view →
COAD	DFS	Tertile	All	0.709	0.839	<.001	41	view →
BLCA	OS	Median	II,III,IV	0.562	0.322	<.001	40	view →
SKCM	OS	Tertile	II,III,IV	0.490	0.256	<.001	39	view →
UCEC	DFS	Tertile	All	0.513	0.718	<.001	34	view →
KICH	OS	Median	All	0.702	1.000	.006	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

VEGFA–KIRP (DFS)

Open the KIRP breakdown →