VEGFA

Across TCGA cell cohorts, VEGFA RNA expression is significantly associated with the go_rna of many other GO terms, with 4,316 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible VEGFA-associated GO terms across cancer lineages are Negative regulation of blood-brain barrier permeability, VEGF-activated platelet-derived growth factor receptor signaling pathway, and Positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway. Each is linked with VEGFA in more than 19 cancer types. Because this analysis shows association rather than direction, both VEGFA-to-partner and partner-to-VEGFA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of blood-brain barrier permeability grouped by VEGFA-low versus VEGFA-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VEGFA→partner) and Y-score (partner→VEGFA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Negative regulation of blood-brain barrier permeability →	+0.513	+2.106	<.001	<.001	3	20
LUNG_SCLC	VEGF-activated platelet-derived growth factor receptor signaling pathway →	+0.721	+1.566	<.001	<.001	3	20
LUNG_SCLC	Positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway →	+0.721	+1.566	<.001	<.001	3	20
BLOOD_Lymphoma	Venous blood vessel morphogenesis →	+0.324	+1.213	<.001	<.001	3	18
LIVER	Endothelial cell chemotaxis →	+0.248	+2.079	<.001	.001	3	18
LUNG_SCLC	Motor neuron migration →	+0.808	+1.714	.002	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,316 associations by consensus.

Negative regulation of blood-brain barrier permeability by VEGFA expression — BLOOD_Lymphoma

Explore this box plot interactively →