VDR

Across TCGA patient cohorts, VDR protein abundance is significantly associated with the RNA expression of many other genes, with 10,984 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible VDR-associated genes across cancer lineages are CHST11, ICAM1, and LYPD6B. Each is linked with VDR in more than 3 cancer types. Because this analysis shows association rather than direction, both VDR-to-partner and partner-to-VDR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, VDR versus CHST11 in OV, with a Pearson correlation of 0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VDR→partner) and Y-score (partner→VDR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CHST11 →	+1.111	+0.589	.003	.005	3	4
LSCC	ICAM1 →	+1.037	+0.398	<.001	<.001	3	4
HNSC	LYPD6B →	-1.361	-0.606	<.001	<.001	3	4
OV	COLEC11 →	-3.135	-0.485	.003	.006	3	3
OV	HSDL2 →	-0.893	-0.390	.009	.007	3	3
OV	C11orf1 →	-0.939	-0.445	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,984 associations by consensus.

VDR vs CHST11 — OV

Explore this scatter interactively →