VDR

Across TCGA pan-cancer cohorts, VDR RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated VDR data layer compared with 9 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher VDR RNA is associated with worse overall survival. In most high-consensus cancer types, elevated VDR expression acts as an unfavorable survival marker, although some lineages such as ESCA and CHOL show a favorable association.

UVM, LGG, and PAAD are the cancer types where VDR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.401	0.890	.001	55	view →
LGG	OS	Median	All	0.722	0.898	<.001	54	view →
PAAD	DFS	Median	All	0.225	0.472	.003	39	view →
ESCA	OS	Median	III,IV	0.712	0.408	.002	36	view →
LAML	DFS	Quartile	All	0.417	0.773	<.001	36	view →
LUSC	DFS	Median	All	0.306	0.450	.003	28	view →
GBM	DFS	Median	All	0.172	0.398	<.001	27	view →
ACC	DFS	Median	All	0.536	0.777	.005	27	view →
CHOL	DFS	Quartile	All	0.759	0.152	.002	24	view →
KIRC	DFS	Median	III,IV	0.589	0.304	.006	22	view →
MESO	OS	Median	All	0.303	0.473	.012	22	view →
HNSC	OS	Tertile	IV	0.457	0.790	.008	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

VDR–UVM (OS)

Open the UVM breakdown →