VDR

Across TCGA patient cohorts, VDR mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VDR-associated genes across cancer lineages are YAP, Annexin-1, and ATM. Each is linked with VDR in more than 1 cancer types. Because this analysis shows association rather than direction, both VDR-to-partner and partner-to-VDR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YAP grouped by VDR-low versus VDR-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VDR→partner) and Y-score (partner→VDR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	YAP →	+0.243	+2.820	.032	.035	3	2
UCEC	Annexin-1 →	+0.563	+2.341	.007	.019	3	2
UCEC	ATM →	-0.668	-2.446	<.001	.018	3	2
UCEC	DJ-1 →	+0.137	+2.183	.041	.033	3	2
UCEC	eEF2 →	+0.291	+2.999	.043	.035	3	1
UCEC	EGFR_pY1068 →	-0.229	-1.906	.023	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

YAP by VDR expression — SKCM

Explore this box plot interactively →