VDR

Across TCGA cell cohorts, VDR mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VDR-associated genes across cancer lineages are SIGLEC5, OR10W1, and OR10Q1. Each is linked with VDR in more than 1 cancer types. Because this analysis shows association rather than direction, both VDR-to-partner and partner-to-VDR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC5 grouped by VDR-low versus VDR-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VDR→partner) and Y-score (partner→VDR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SIGLEC5 →	+0.019	+5.415	<.001	.004	3	1
LARGE_INTESTINE	OR10W1 →	+0.019	+4.562	<.001	<.001	3	1
LARGE_INTESTINE	OR10Q1 →	+0.105	+3.920	.002	.005	3	1
BLOOD_Leukemia	OR1D4 →	+0.069	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

SIGLEC5 by VDR expression — SKIN

Explore this box plot interactively →