VDAC2P2

Across TCGA pan-cancer cohorts, VDAC2P2 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of VDAC2P2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where VDAC2P2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types VDAC2P2 is over-expressed in tumor, although a few such as BRCA and THCA show the opposite, repressed pattern.

KIRC, BRCA, and THCA are the cancer types where VDAC2P2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VDAC2P2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.040	<.001	9	view →
BRCA	All	III,IV	−0.109	.001	4	view →
THCA	All	All	−0.049	<.001	3	view →
LIHC	Female	II,III,IV	−0.020	.033	2	view →
COAD	All	II,III,IV	−0.029	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

VDAC2P2–KIRC

Open the KIRC breakdown →