VDAC1P4

Across TCGA pan-cancer cohorts, VDAC1P4 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated VDAC1P4 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher VDAC1P4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated VDAC1P4 expression acts as an unfavorable survival marker, although some lineages such as READ and SKCM show a favorable association.

BLCA, ACC, and STAD are the cancer types where VDAC1P4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Quartile	IV	0.271	0.515	<.001	80	view →
ACC	OS	Quartile	All	0.704	0.908	<.001	52	view →
STAD	OS	Quartile	II,III,IV	0.346	0.754	.003	51	view →
READ	DFS	Tertile	All	0.791	0.444	.001	32	view →
SKCM	OS	Median	All	0.924	0.826	.002	28	view →
UCEC	DFS	Median	All	0.575	0.692	.013	22	view →
KICH	OS	Quartile	III,IV	0.194	0.833	.006	20	view →
LIHC	DFS	Tertile	All	0.188	0.319	.014	17	view →
HNSC	DFS	Median	IV	0.663	0.491	.005	13	view →
CHOL	OS	Tertile	All	0.164	0.861	.004	12	view →
COAD	DFS	Tertile	IV	0.372	0.616	.028	9	view →
SARC	OS	Tertile	All	0.755	0.884	.012	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

VDAC1P4–BLCA (OS)

Open the BLCA breakdown →