VDAC1P4

Across TCGA pan-cancer cohorts, VDAC1P4 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of VDAC1P4’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where VDAC1P4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types VDAC1P4 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

LIHC, BRCA, and LUSC are the cancer types where VDAC1P4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VDAC1P4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	III,IV	+0.038	.019	5	view →
BRCA	All	All	+0.146	.017	4	view →
LUSC	All	All	+0.059	.003	3	view →
LUAD	All	All	+0.190	.014	2	view →
CHOL	All	All	+0.076	.035	1	view →
THCA	Female	All	−0.028	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

VDAC1P4–LIHC

Open the LIHC breakdown →