VCX3A

Across TCGA patient cohorts, VCX3A mutation is significantly associated with the RNA expression of many other genes, with 70 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VCX3A-associated genes across cancer lineages are CYCSP26, NCLP2, and SLC16A12-AS1. Each is linked with VCX3A in more than 1 cancer types. Because this analysis shows association rather than direction, both VCX3A-to-partner and partner-to-VCX3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYCSP26 grouped by VCX3A-low versus VCX3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VCX3A→partner) and Y-score (partner→VCX3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CYCSP26 →	+0.167	+3.299	<.001	.006	3	2
SKCM	NCLP2 →	+0.020	+3.669	.004	.006	3	1
SKCM	SLC16A12-AS1 →	+0.034	+4.469	<.001	.006	3	1
SKCM	RPL35AP19 →	+0.132	+3.451	.005	.006	3	1
SKCM	RPS3AP17 →	+0.028	+4.199	.006	.009	3	1
UCEC	RPL32P36 →	+0.148	+2.863	.008	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

CYCSP26 by VCX3A expression — UCEC

Explore this box plot interactively →