VCX3A

Across TCGA pan-cancer cohorts, VCX3A RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of VCX3A’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where VCX3A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types VCX3A is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

LUSC, KICH, and LIHC are the cancer types where VCX3A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VCX3A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	All	+0.300	<.001	6	view →
KICH	All	All	+0.117	.001	5	view →
LIHC	Male	All	+0.167	<.001	4	view →
HNSC	Male	II,III,IV	+0.074	.020	3	view →
KIRP	Female	All	+0.140	.015	2	view →
STAD	Male	All	+0.073	.010	2	view →
THCA	All	All	−0.042	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

VCX3A–LUSC

Open the LUSC breakdown →