VCX3A

Across TCGA patient cohorts, VCX3A mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VCX3A-associated genes across cancer lineages are PDK1_pS241, p70-S6K_pT389, and Rad50. Each is linked with VCX3A in more than 1 cancer types. Because this analysis shows association rather than direction, both VCX3A-to-partner and partner-to-VCX3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDK1_pS241 grouped by VCX3A-low versus VCX3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VCX3A→partner) and Y-score (partner→VCX3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDK1_pS241 →	+0.210	+3.013	.033	.019	3	1
UCEC	p70-S6K_pT389 →	-0.234	-3.000	.033	.037	1	1
UCEC	Rad50 →	-0.303	-3.000	.030	.037	1	1
UCEC	STAT3_pY705 →	-0.415	-3.000	.006	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

PDK1_pS241 by VCX3A expression — UCEC

Explore this box plot interactively →