VCX2

Across TCGA patient cohorts, VCX2 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VCX2-associated genes across cancer lineages are RNU6-591P, LYPLA1P1, and RPL23AP90. Each is linked with VCX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both VCX2-to-partner and partner-to-VCX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-591P grouped by VCX2-low versus VCX2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VCX2→partner) and Y-score (partner→VCX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-591P →	+0.373	+7.741	<.001	.009	3	2
UCEC	LYPLA1P1 →	+0.096	+4.464	<.001	.005	3	2
UCEC	RPL23AP90 →	+0.458	+3.004	.002	.006	3	1
COAD	MBD3L3 →	+0.129	+7.741	<.001	.009	3	1
UCEC	SLCO1B1 →	+0.277	+3.085	.006	.005	3	1
COAD	MIR1263 →	+1.494	+7.741	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

RNU6-591P by VCX2 expression — COAD

Explore this box plot interactively →