VCPKMT

Across TCGA patient cohorts, VCPKMT mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VCPKMT-associated genes across cancer lineages are MIR548F4, SDAD1P4, and SNX3P1Y. Each is linked with VCPKMT in more than 1 cancer types. Because this analysis shows association rather than direction, both VCPKMT-to-partner and partner-to-VCPKMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR548F4 grouped by VCPKMT-low versus VCPKMT-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VCPKMT→partner) and Y-score (partner→VCPKMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR548F4 →	+0.333	+7.924	<.001	.008	3	1
SKCM	SDAD1P4 →	+0.053	+5.159	<.001	.007	3	1
UCEC	SNX3P1Y →	+0.224	+5.893	<.001	<.001	3	1
UCEC	RN7SL32P →	+0.392	+3.699	.005	.004	3	1
UCEC	MIR4499 →	+0.388	+3.344	.002	.007	3	1
LUAD	RNU6-206P →	+0.448	+6.912	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

MIR548F4 by VCPKMT expression — LUSC

Explore this box plot interactively →