VCP

Across TCGA pan-cancer cohorts, VCP mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of VCP’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where VCP mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types VCP is over-expressed in tumor, although a few such as HNSC and PDAC show the opposite, repressed pattern.

COAD, LSCC, and HNSC are the cancer types where VCP tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VCP mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+0.106	.001	6	view →
LSCC	Male	All	+0.211	<.001	4	view →
HNSC	Male	All	−0.104	.024	4	view →
OV	All	All	+0.300	.003	2	view →
PDAC	Female	III,IV	−0.272	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

VCP–COAD

Open the COAD breakdown →