VCP

Across TCGA patient cohorts, VCP RNA expression is significantly associated with the go_rna of many other GO terms, with 7,148 significant associations in total. OV shows the largest number of these associations.

The most reproducible VCP-associated GO terms across cancer lineages are Positive regulation of chromosome condensation, Regulation of chromosome condensation, and tRNA transport. Each is linked with VCP in more than 29 cancer types. Because this analysis shows association rather than direction, both VCP-to-partner and partner-to-VCP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of chromosome condensation grouped by VCP-low versus VCP-high in DLBC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VCP→partner) and Y-score (partner→VCP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	Positive regulation of chromosome condensation →	+0.117	+0.512	<.001	<.001	3	30
DLBC	Regulation of chromosome condensation →	+0.094	+0.543	<.001	<.001	3	30
SCLC	tRNA transport →	+0.165	+0.482	<.001	<.001	3	30
DLBC	Meiotic chromosome condensation →	+0.120	+0.569	<.001	<.001	3	29
DLBC	Negative regulation of cilium assembly →	+0.058	+0.465	<.001	<.001	3	28
DLBC	Mitotic chromosome condensation →	+0.090	+0.536	<.001	<.001	3	28

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,148 associations by consensus.

Positive regulation of chromosome condensation by VCP expression — DLBC

Explore this box plot interactively →