VCP

Across TCGA patient cohorts, VCP protein abundance is significantly associated with the RNA expression of many other genes, with 5,533 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible VCP-associated genes across cancer lineages are RGP1, PIGO, and NFX1. Each is linked with VCP in more than 5 cancer types. Because this analysis shows association rather than direction, both VCP-to-partner and partner-to-VCP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, VCP versus RGP1 in OV, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VCP→partner) and Y-score (partner→VCP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RGP1 →	+0.644	+0.304	<.001	<.001	3	6
PDAC	PIGO →	+0.679	+0.380	<.001	<.001	3	6
OV	NFX1 →	+0.774	+0.321	<.001	<.001	3	6
LSCC	TESK1 →	+0.718	+0.318	<.001	<.001	3	5
OV	BAG1 →	+0.617	+0.205	.001	.007	2	6
LSCC	SIGMAR1 →	+0.761	+0.253	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,533 associations by consensus.

VCP vs RGP1 — OV

Explore this scatter interactively →