VCP

Across TCGA patient cohorts, VCP mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VCP-associated genes across cancer lineages are eIF4E, FoxM1, and mTOR_pS2448. Each is linked with VCP in more than 1 cancer types. Because this analysis shows association rather than direction, both VCP-to-partner and partner-to-VCP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by VCP-low versus VCP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VCP→partner) and Y-score (partner→VCP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.182	+2.169	.011	.003	3	2
UCEC	FoxM1 →	+0.202	+1.514	.021	.015	3	2
UCEC	mTOR_pS2448 →	-0.114	-1.565	.025	.034	3	2
UCEC	Notch1 →	+0.179	+1.807	<.001	.004	3	2
UCEC	PRDX1 →	+0.174	+1.678	.013	.021	3	2
UCEC	ATM →	-0.464	-2.137	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

eIF4E by VCP expression — UCEC

Explore this box plot interactively →