VCP

Across TCGA cell cohorts, VCP mutation is significantly associated with the mutation status of many other genes, with 3,664 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VCP-associated genes across cancer lineages are FASN, SZT2, and RASGRP2. Each is linked with VCP in more than 3 cancer types. Because this analysis shows association rather than direction, both VCP-to-partner and partner-to-VCP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by VCP-low versus VCP-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VCP→partner) and Y-score (partner→VCP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FASN →	+4.942	+4.942	.001	.001	1	4
STOMACH	SZT2 →	+2.942	+4.025	.009	.009	1	4
BLOOD_Lymphoma	RASGRP2 →	+4.969	+4.014	.008	.008	1	4
BLOOD_Leukemia	KCNB2 →	+3.430	+3.313	.005	.005	1	4
BLOOD_Leukemia	ANKFY1 →	+3.360	+3.946	<.001	<.001	1	4
BLOOD_Lymphoma	SYNGAP1 →	+3.554	+3.731	.003	.003	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,664 associations by consensus.

FASN by VCP expression — STOMACH

Explore this box plot interactively →