VCL

Across TCGA pan-cancer cohorts, VCL mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of VCL’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where VCL mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types VCL is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, LUAD, and LSCC are the cancer types where VCL tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VCL mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−1.595	<.001	11	view →
LUAD	Female	III,IV	−0.893	<.001	9	view →
LSCC	Female	All	−1.017	<.001	8	view →
PDAC	Male	All	+0.722	<.001	8	view →
CCRCC	Male	III,IV	−0.569	<.001	8	view →
HNSC	Male	All	−0.259	<.001	8	view →
OV	All	All	−0.721	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

VCL–COAD

Open the COAD breakdown →