VCL

Across TCGA patient cohorts, VCL protein abundance is significantly associated with the RNA expression of many other genes, with 18,446 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible VCL-associated genes across cancer lineages are ACTA2, EFEMP1, and CALD1. Each is linked with VCL in more than 9 cancer types. Because this analysis shows association rather than direction, both VCL-to-partner and partner-to-VCL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, VCL versus ACTA2 in UCEC, with a Pearson correlation of 0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VCL→partner) and Y-score (partner→VCL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACTA2 →	+1.802	+0.621	<.001	<.001	3	10
UCEC	EFEMP1 →	+1.480	+0.638	<.001	<.001	3	10
BRCA	CALD1 →	+1.240	+0.506	<.001	<.001	3	10
OV	ISLR →	+1.728	+0.586	<.001	<.001	3	10
UCEC	CNN1 →	+2.828	+0.767	<.001	<.001	3	10
BRCA	AOC3 →	+1.340	+0.419	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,446 associations by consensus.

VCL vs ACTA2 — UCEC

Explore this scatter interactively →