VCL

Across TCGA patient cohorts, VCL mutation is significantly associated with the RNA expression of many other genes, with 6,326 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VCL-associated genes across cancer lineages are DEFB127, PBK, and RNA5SP525. Each is linked with VCL in more than 2 cancer types. Because this analysis shows association rather than direction, both VCL-to-partner and partner-to-VCL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB127 grouped by VCL-low versus VCL-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VCL→partner) and Y-score (partner→VCL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	DEFB127 →	+0.049	+4.020	<.001	.009	3	3
SKCM	PBK →	+0.977	+3.341	.008	.005	3	3
SKCM	RNA5SP525 →	+0.149	+4.049	<.001	.007	3	3
UCEC	OIP5 →	+0.810	+1.847	<.001	<.001	3	3
UCEC	DNAJC8 →	+0.331	+1.530	<.001	<.001	3	3
UCEC	PSMC3IP →	+0.681	+1.836	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,326 associations by consensus.

DEFB127 by VCL expression — CESC

Explore this box plot interactively →