VCL

Across TCGA patient cohorts, VCL mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VCL-associated genes across cancer lineages are ACC_pS79, JNK2, and Shc_pY317. Each is linked with VCL in more than 1 cancer types. Because this analysis shows association rather than direction, both VCL-to-partner and partner-to-VCL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC_pS79 grouped by VCL-low versus VCL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VCL→partner) and Y-score (partner→VCL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC_pS79 →	+0.211	+1.280	.030	.049	3	2
UCEC	JNK2 →	+0.193	+1.884	<.001	.001	3	2
UCEC	Shc_pY317 →	-0.167	-1.447	<.001	.002	3	2
UCEC	ATM →	-0.450	-3.156	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.395	+1.242	.017	.020	3	2
UCEC	4E-BP1 →	+0.335	+1.830	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

ACC_pS79 by VCL expression — UCEC

Explore this box plot interactively →