VCL

Across TCGA cell cohorts, VCL RNA expression is significantly associated with the go_rna of many other GO terms, with 5,588 significant associations in total. BONE shows the largest number of these associations.

The most reproducible VCL-associated GO terms across cancer lineages are Regulation of focal adhesion assembly, Regulation of cell-substrate junction assembly, and Regulation of cell-substrate junction organization. Each is linked with VCL in more than 16 cancer types. Because this analysis shows association rather than direction, both VCL-to-partner and partner-to-VCL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of focal adhesion assembly grouped by VCL-low versus VCL-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VCL→partner) and Y-score (partner→VCL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of focal adhesion assembly →	+0.152	+1.655	<.001	<.001	3	17
BONE	Regulation of cell-substrate junction assembly →	+0.152	+1.655	<.001	<.001	3	17
BONE	Regulation of cell-substrate junction organization →	+0.141	+1.753	<.001	<.001	3	16
BONE	Regulation of cell-substrate adhesion →	+0.119	+1.429	<.001	<.001	3	15
BONE	Positive regulation of focal adhesion assembly →	+0.195	+1.483	<.001	<.001	3	14
BONE	Regulation of cell-matrix adhesion →	+0.141	+1.411	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,588 associations by consensus.

Regulation of focal adhesion assembly by VCL expression — BONE

Explore this box plot interactively →